tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate
(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-Dimethylethyl Ester
CAS: 273206-92-1
Molecular Formula: C10H18N2O2
tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate - Names and Identifiers
tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H18N2O2 |
| Molar Mass | 198.27 |
| Density | 1.144 |
| Boling Point | 275℃ |
| Flash Point | 120℃ |
| pKa | 8.52±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate - Risk and Safety
| Hazard Class | IRRITANT |
tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.044 ml | 25.219 ml | 50.439 ml |
| 5 mM | 1.009 ml | 5.044 ml | 10.088 ml |
| 10 mM | 0.504 ml | 2.522 ml | 5.044 ml |
| 5 mM | 0.101 ml | 0.504 ml | 1.009 ml |
Last Update：2024-01-02 23:10:35
tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate - Reference Information
| Application | fluoroquinolones are mainly used for the treatment of respiratory infections, urinary tract infections, sexually transmitted diseases, skin and Skin soft tissue infections. (1 α,5 α,6 α)-6-amino-3-azabicyclo [3.1.0] hexane-3-carboxylic acid 1, 1-dimethylethyl Ester is an intermediate for the preparation of histone deacetylase (HDAC) inhibitors with Class I selectivity and good oral bioavailability. It can be used in the synthesis of alatoxacin mesylate. |
| preparation | preparation of REL-(1R,5S,6S)-6-amino-3-azabicyclo [3.1.0] hexane-3-carboxylic acid tert-butyl ester. Take three dry reaction bottles, one with a calcium chloride dryer, one with a dropping funnel, tetrahydrofuran solution to be anhydrous treatment in advance. Weigh tert-butyl formyl chloride and dissolve in 180mL anhydrous tetrahydrofuran solution, start stirring device. After dissolution, the solution was slowly added to 200ml of tetrahydrofuran solution (3-azabicyclo [3.1.0] hexane-6-amine was dissolved in tetrahydrofuran solution) in ice-water bath condition, solid was precipitated immediately, and stirring was continued at 35 ° C. For 4 hours after addition. The reaction progress was checked by thin layer chromatography. After completion of the reaction, the reaction solution was cooled, 400ml of ice water was added to the reaction to complete precipitation of the product, and a pale yellow solid was obtained by Suction filtration. After drying, it was crystallized from absolute ethanol to obtain tert-butyl REL-(1R,5S,6S)-6-amino-3-azabicyclo [3.1.0] hexane-3-carboxylate. |
Last Update：2024-04-10 22:29:15
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Product Name: (1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-Dimethylethyl Ester Visit Supplier Webpage Request for quotation
CAS: 273206-92-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 273206-92-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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